AAO

You are currently browsing articles tagged AAO.

PO417: Non-contact, Rapid, Visual Multifocal Diagnosis of Multiple Sclerosis

October 13, 2010 in Conference, Poster, Publication

Program/Poster: Hall A – PO417
AAO 2010 Annual Meeting, Chicago USA, 2-6 May 2010

Presentation: Monday, Oct 18 2010 11:00AM-12:30PM

Authors

Ted Maddess1, PhD; Christian J Lueck1,2, MD, FRCP;
Cristian Voicu1,2, MD, PhD; and Andrew Charles James1, PhD.
1ARC Centre of Excellence in Vision Science, Australian National University, Canberra, Australia
2Department of Neurology, The Canberra Hospital, Canberra, Australia.

Purpose

To examine the diagnostic power of the TrueField Analyzer (TFA) in multiple sclerosis (MS).

Methods

Thirty-five normal (47.9 ± 16.8 years, 22 women) and 85 MS subjects (49.8 ± 11.3 years, 62 women) were enrolled; including 2 primary and 11 secondary progressives (PS), the remainder relapsing remitting (RR). EDSS scores for RR patients were 3.53 ± 1.04 (mean ± SD), and 5.9 ± 1.43 for PS. The TFA stimuli tested 44 regions/eye within the central 60 degrees.

Results

%AUC for the 144 RR eyes was 75.0 ± 3.31 (mean ± SE) and for the 26 PS eyes it was 94.8 ± 3.55. For RR patients that had or had not experienced ON, %AUC was 75.7 ± 4.48 and 75.4 ± 3.84, respectively.

Conclusion

ON had no significant effect, and PS patients had %AUC consistent with EDSS scores, suggesting that the results were more dependent on “secondary” degeneration than inflammation history.

Downloads

PO417 Poster     PPT Presentation

AAO 2010 Annual Meeting & Exhibition

October 12, 2010 in Conference, Poster, Publication

AAO 2010

The TrueField Analyzer

Objective • Bilateral • Rapid • Pupil Perimetry

We will be at the AAO 2010 Annual Meeting & Exhibition – come and see us to learn about the new work and recent developments. Call 1-877-811-8113 or 508-517-8012 to arrange a meeting at the show.

Dr Ted Maddess, Australian National University

Dr Maddess will present the following poster paper at the AAO meeting detailing new and exciting clinical developments.

PO417: Non-contact, Rapid, Visual Multifocal Diagnosis of Multiple Sclerosis

Ted Maddess1, PhD; Christian J Lueck1,2, MD, FRCP;
Cristian Voicu1,2, MD, PhD; and Andrew Charles James1, PhD.
1ARC Centre of Excellence in Vision Science;
2Department of Neurology, The Canberra Hospital
Australian National University, Canberra, Australia

Location:

Hall A – PO417

Dr Maddess presentation:

Mon Oct 18, 2010, 11am-12:30pm

AAO Link:

PO417 – Dr T. Maddess

Download:

Download Poster & Paper

ABSTRACT:

Purpose: To examine the diagnostic power of the TrueField Analyzer (TFA) in multiple sclerosis (MS).

Methods: Thirty-five normal (47.9 ± 16.8 years, 22 women) and 85 MS subjects (49.8 ± 11.3 years, 62 women) were enrolled; including 2 primary and 11 secondary progressives (PS), the remainder relapsing remitting (RR). EDSS scores for RR patients were 3.53 ± 1.04 (mean ± SD), and 5.9 ± 1.43 for PS. The TFA stimuli tested 44 regions/eye within the central 60 degrees.

Results: %AUC for the 144 RR eyes was 75.0 ± 3.31 (mean ± SE) and for the 26 PS eyes it was 94.8 ± 3.55. For RR patients that had or had not experienced ON, %AUC was 75.7 ± 4.48 and 75.4 ± 3.84, respectively.

Conclusion: ON had no significant effect, and PS patients had %AUC consistent with EDSS scores, suggesting that the results were more dependent on “secondary” degeneration than inflammation history.

Field-Balanced Multifocal Objective Perimetry

October 21, 2009 in Conference, Paper, Publication

AAO Free Paper: PA059: Field-Balanced Multifocal Objective Perimetry
AAO 2009 Annual Meeting, San Francisco, CA, October 24-27, 2009

Presentation: Monday Oct 26, 2009, 3:21 PM, Room NORTH 133

Background

Perimeters have poor repeatability and reliability. In an attempt to ameliorated these problems we developed a rapid, objective, noncontact multifocal perimeter. Data is not collected during fixation losses or blinks. Here we improve the method.

Precis

This study seeks to improve a new FDA approved, non-contact, objective perimeter: the TrueField Analyzer, which simultaneously assesses 44 visual field regions of each eye in 4 to 6 minutes recording time; response amplitude (sensitivity), response delay, measurement error, and data on afferent and efferent pupil defects, are provided at every field location; a 20% improvement in reliability and excellent diagnostic accuracy was obtained.

Abstract

Authors

T. Maddess., M. Kolic, R.W. Essex, A.C. James
ARC Centre of Excellence in Vision Science, Dept Ophthalmology The Canberra Hospital, Australian National University, Canberra, Australia.

Purpose

To compare 8 TrueField Analyzer methods.

Methods

Two blocks of trials contained 41 normal and 47 glaucoma subjects, and 40 normals and 39 patients. We compared 4 or 6 min stimulus durations and 2 methods of balancing luminances in an attempt to produce higher median reliability across the field as measured by t-statics for each field region. The dichoptic stimuli extended to 30 deg eccentricity. Maximum luminance and stimulus presentation rate were also varied. All subjects were also examined with Matrix and HFA perimetry, and Stratus OCT.

Results

The 44 region/eye, 1/s stimuli, gave areas under ROC plots of: moderate + severe fields of 0.86 ± 0.04, severe 0.98 ± 0.01. Median t-statistics improved by 20% to 3.28 ± 0.45.

Conclusion

High diagnostic accuracy and median t-stats were obtained from this improved binocular method.

Downloads

Check back here after the meeting to download the full paper.

AAO 2009 – Booth 2619

February 17, 2009 in Conference

Come and see The TrueField Analyzer (TFA) at this year’s AAO – booth #2619.

AAO Booth 2619

See the new TFA device in operation with updated test protocols and refined operator software.

If you have any interest in visual fields, then the TrueField Analyzer is the perimeter you need to see!

The TrueField Analyzer

Objective • Bilateral • Rapid • Pupil Perimetry

Map of AAO Booth 2619- AAO site

Dr Ted Maddess, Australian National University

Dr Maddess will present the following free paper at the AAO meeting describing the TFA device, background technology and details of recent clinical performance:

PA059: Field-Balanced Multifocal Objective Perimetry

T. Maddess., M. Kolic, R.W. Essex, A.C. JamesARC Centre of Excellence in Vision Science, Dept Ophthalmology The Canberra Hospital, Australian National University, Canberra, Australia

Time:

Monday Oct 26, 2009, at 3:21 PM

Location:

Room: North 133

AAO Link:

PA059 – Dr T. Maddess
ABSTRACT: Purpose: To compare 8 TrueField Analyzer methods.Methods: Two blocks of trials contained 41 normal and 47 glaucoma subjects, and 40 normals and 39 patients. We compared 4 or 6 min stimulus durations and 2 methods of balancing luminances in an attempt to produce higher median reliability across the field as measured by t-statics for each field region. The dichoptic stimuli extended to 30 deg eccentricity. Maximum luminance and stimulus presentation rate were also varied. All subjects were also examined with Matrix and HFA perimetry, and Stratus OCT.Results: The 44 region/eye, 1/s stimuli, gave areas under ROC plots of: moderate + severe fields of 0.86 ± 0.04, severe 0.98 ± 0.01. Median t-statistics improved by 20% to 3.28 ± 0.45.Conclusion: High diagnostic accuracy and median t-stats were obtained from this improved binocular method.

See the new TFA device in operation with updated test protocols and refined operator software. If you have any interest in visual fields, then the TrueField Analyzer is the perimeter you need to see!

AAO 2008 – Booth 4241

November 5, 2008 in Conference, Paper, Publication

Come and see The TrueField Analyzer (TFA) at this year’s AAO – booth #4241.

AAO Booth 4241

See the new TFA device in operation with updated test protocols and refined operator software.

If you have any interest in visual fields, then the TrueField Analyzer is the perimeter you need to see!

The TrueField Analyzer

Objective • Bilateral • Rapid • Pupil Perimetry

Map of AAO Booth 4241 – AAO site

Dr Ted Maddess, Australian National University

Dr Maddess will present the following paper at AAO describing the TFA device, its background technology and details of recent clinical performance:

PA042: Pupillographic Multifocal Objective Perimetry for Glaucoma

T. Maddess , A.C. James., X.L. Goh, M. Kolic. ARC Centre of Excellence in Vision Science, CVS, Australian National University, Canberra, Australia.

Time:

Monday Nov 10, 2008 at 10:22 AM

Location:

Room A411

AAO Link:

PA042 – Dr T. Maddess

AAO Session:

FP04 Glaucoma Original Paper Session
ABSTRACT: Purpose: To investigate 4 variants of multifocal pupillographic perimetry using a prototype of the TrueField Analyser, which objectively assesses both visual fields concurrently. Methods: We tested 42 normal and 44 glaucoma subjects. Multifocal stimuli of 4 min. duration were presented dichoptically with 24 or 44 regions/eye extending to 30 deg eccentricity. Presentation rates per region were 0.25, 1, or 4 /s. All subjects were also examined with Matrix and HFA perimetry, and Stratus OCT. Results: The 44 region, 1 presentation/s stimuli, gave areas under ROC plots for mild, moderate, and severe fields of 0.743, 0.808, 0.964. Conclusion: Excellent diagnostic accuracy for test durations of 2 min/eye were obtained from this new binocular method.

Pupillographic Multifocal Objective Perimetry for Glaucoma

November 5, 2008 in Conference, Paper, Publication | No comments

American Acadamy of Ophthalmology Annual Meeting, Atlanta GA., 8-11 November 2008.

Authors

T. Maddess , A.C. James., X.L. Goh, M. Kolic. ARC Centre of Excellence in Vision Science, CVS, Australian National University, Canberra, Australia.

Presentation details

Time:

Monday Nov 10, 2008 at 10:22 AM

Location:

Room A411

AAO Link:

PA042 – Dr T. Maddess

AAO Session:

FP04 Glaucoma Original Paper Session

Purpose

To investigate 4 variants of multifocal pupillographic perimetry using a prototype of the TrueField Analyser, which objectively assesses both visual fields concurrently.

Methods

We tested 42 normal and 44 glaucoma subjects. Multifocal stimuli of 4 min. duration were presented dichoptically with 24 or 44 regions/eye extending to 30 deg eccentricity. Presentation rates per region were 0.25, 1, or 4 /s. All subjects were also examined with Matrix and HFA perimetry, and Stratus OCT.

Results

The 44 region, 1 presentation/s stimuli, gave areas under ROC plots for mild, moderate, and severe fields of 0.743, 0.808, 0.964.

Conclusion

Excellent diagnostic accuracy for test durations of 2 min/eye were obtained from this new binocular method.

Downloads

Not available yet – check back here after the AAO meeting.

Optimizing pupillographic multifocal objective perimetry for glaucoma

November 10, 2007 in Conference, Poster, Publication

Poster #098. AAO 2007 Annual Meeting, New Orleans, 10-13 November 2007

Authors

AC James, XL Goh, T Maddess. ARC Centre of Excellence in Vision Science, Centre for Visual Sciences, Australian National University, Canberra, Australia.

PURPOSE

To investigate 10 variants of multifocal pupillographic perimetry in glaucoma.

METHODS

We tested 22 normal and 23 glaucoma subjects. Multifocal stimuli of four-minute duration were presented dichoptically with 24 regions/eye extending to 30 degrees eccentricity. Stimulus sets differed in the presentation rate per region (0.25, 1, 4, presentations/sec.), stimulus duration/presentation (66, 133, or 266 ms), flicker rate on each presentation (0, 15, or 30 Hz), and peak luminosity (80, 150, and 290 cd/m2).

RESULTS

The brightest, four presentation/sec. stimuli, with 30Hz flicker gave sensitivities and specificities of 95.5% using response amplitude and delay.

CONCLUSIONS

Good accuracy for test durations of two minutes/eye could be obtained from this objective method.

Downloads

Download the full paper here

Dichoptic pupillographic multifocal visual field assessment for glaucoma

November 10, 2007 in Conference, Poster, Publication | No comments

Poster #091. AAO 2007 Annual Meeting, New Orleans, 10-13 November 2007.

Authors

T Maddess, XL Goh, AC James. ARC Centre of Excellence in Vision Science, Centre for Visual Sciences, Australian National University, Canberra, Australia.

PURPOSE

To investigate eight variants of multifocal pupillographic perimetry in glaucoma.

METHODS

Experiment 1: We tested 87 normal and 82 glaucoma subjects. Multifocal stimuli of four-minutes duration were presented dichoptically. The four stimulus sets adopted either two or four presentations/sec/region, and a flicker rate on each presentation of 15 or 30 Hz. The 24 region T30-24 pattern (Fig 1) was used. Data from fixation losses, blinks, etc. were automatically excluded.

Experiment 2: We examined 20 normal and 20 glaucoma subjects, that were tightly age and sex matched and had moderate to severe fields in at least one eye. The 40 region T30-40 pattern (Fig 1) was used. Stimuli were present at 1/s, 1/4s, or 1/16s and either flickered at 20 Hz for up to 100 ms or had a single 33 ms pulse.

RESULTS:

Experiment 1: Using the area of the pupillary responses for the 4/s, 30 Hz test, areas under ROC plots ranged from 0.74 for moderate fields to 0.81 for more severe fields. The largest age effect was –0.10 µm of contraction amplitude per decade (P <.0001).

Experiment 2: For discriminant functions including response amplitude or area and time to peak had AUC values of 0.89 to 0.93 for the short pulse stimulus. The very slow stimulus had the worst diagnostic performance.

CONCLUSIONS

These are preliminary reports of ongoing studies that indicate that rapid and objective functional testing for glaucoma may be practical.

Downloads

Download the full paper here